Applications and innovations for 2D in vitro cell migration and invasion studies
We review here the wide range of applications enabled by the in vitro wound healing assay, alongside practical guidelines to study and analyze cell migration. Through quantitative and qualitative analysis, … read more
Cardiac assays & 3D cell culture
A necessary step in the path to adequately reproducing human tissue structure in vitro is the formation of complex 3D structures. Cells grown as monolayers on surfaces that are much stiffer than the human … read more
3D Cell Culture & Cell Confinement
The problems of dissimilarity between 2D cell culture and a cell’s natural environment have become evident after numerous studies demonstrated that the cellular microenvironment … read more
Revolutionizing cell culture by implementing adhesive micropatterns to control the microenvironment
The problems of dissimilarity between 2D cell culture and a cell’s natural environment have become evident after numerous studies demonstrated that the cellular microenvironment … read more
Discovering 3D cell culture through a modern microfluidic device, the microchannels
Cells in the body are physically confined by neighboring cells, tissues, and the extracellular matrix. Then, the microenvironment surrounding a cell significantly influences … read more
Control, guide and evaluate outgrowth of neuronal culture
Neurons are often cultured in vitro on a flat, open, and rigid substrate, a platform that does not reflect well the native microenvironment of the brain. The cell’s microenvironment is defined by … read more
ORGAN IN WELL – HEPATOTOXICITY
New technologies for the prediction of hepatotoxicity during preclinical studies
Considered as the main reason to remove drugs from the market, drug induced liver injury (DILI) is a major concern of pharmaceuticals industries to decrease the hepatotoxicity of drugs… read more
ORGAN IN WELL – CARDIOTOXICITY
New technologies for the prediction of cardiotoxicity during preclinical studies
Drug safety is among the main concerns of pharmaceuticals who fight to improve it. In fact, both the long-term and the high costs of drug development lead to an urgent improvement… read more
Discovery of their properties and emphasis on the assays used to test them
Fibroblasts are mesenchymal cells, which provide support and structure to the functional cells of the organs. They are major producers of collagen and other extracellular matrix (ECM) components, and are able to… read more
Explore all the potential of these 3D cell culture assays
The usage of 3D cell culture is increasing in oncology, cell biology and tissue engineering. It provides the accessibility and flexibility of in vitro culture while providing a platform that more closely resembles the 3D structure… read more
