Cell differentiation assay

Cell fate determination and maintenance with stiffness & its environment topography

4DCELL DEVICE

Microgrooves

READ-OUTS

Cell organization

STANDARD CULTURE LIMITATION

In standard cultures, cardiomyocytes derived from pluripotent stem cells have random shapes, are not organized thus showing immature properties.

CELL DIFFERENTIATION ASSAY

Cardiomyocytes differentiate in substartes with topographical cues, as grooved surfaces,  show natural alignment and nuclear elongation.

EXAMPLE

Difference of cell and nuclear elongation in cloned cardiac stem cells on microgrooved substrate versus common flat assays.

microgroove application