Human 3D in vitro models
for drug discovery and preclinical testing
Organ-in-a-well® Platform.
4Dcell develops human in vitro models and experimental platforms to investigate how drug candidates affect cell and tissue function.
SmartHeart® Platform
Drug efficacy and cardiotoxicity
A 96-well human cardiac microtissue platform for measuring contractility, electrical activity and calcium dynamics.
Self-assembling human cardiac microtissues
Human iPSC-derived cardiomyocytes and cardiac fibroblasts self-assemble into ring-shaped 3D microtissues around a central pillar.
Mechanical resistance to tissue contraction
The central pillar provides mechanical resistance as the tissues contract, enabling the study of human cardiac tissue contraction under load.
Multiple tissues to assess response consistency
9 microtissues per well enable tissue-level measurements and assessment of response consistency within each experimental condition.
NAM expertise for your drug discovery programs
4Dcell works alongside pharmaceutical and biotechnology teams to translate biological questions into human in vitro studies. Our expertise in New Approach Methodologies (NAMs) combines model development, functional characterization and compound testing, with experimental conditions and measurements defined around each project’s objectives.
CUSTOM HUMAN IN VITRO MODELS
Develop and characterize human in vitro models tailored to your research question. 4Dcell SmartContractility and SmartSphero platforms provide the foundation for building 3D tissue models, with the platform selected according to the biological and mechanical requirements of your project.
Cell culture technologies and consumables
Use 4Dcell platforms and consumables in your own laboratory to build 3D cell models and control their physical environment. Explore technologies for tissue formation, cell organization and mechanical studies.
Hydrogel-based microwell plates designed to support reproducible formation of spheroids and organoids.
An anchoring system retains tissues during medium changes and imaging.
Homogenous confinement of cells between two parallel planes to a defined micrometer height with sub micrometer resolution.
WHY 4DCELL?
CELL BIOLOGY, BIOPHYSICS AND ENGINEERING COMBINED
4Dcell brings together biologists and engineers to design the physical environments in which cells organize and function.
We use our expertise in microfabrication and 3D cell culture to develop platforms for tissue formation, control of cell geometry and functional analysis. We design these technologies with practical laboratory use in mind, from cell seeding to imaging and measurement.
Our ambition is to equip researchers with the human in vitro models and experimental tools they need to develop the next generation of therapies.